FAQ's

It is advised to first clean the oozing blood & dry the wound area before applying Surgbond. However, if some blood is still left on the epidermal layer, and it comes in contact with Surgbond, it will not have any issues. 

However, if there is a cut in an artery or a vein & blood is oozing out profusely, then Surgbond should not be applied. If applied, it will cause blood to clot, which might be fatal.

Surgbond should not be applied like a layer i.e. the applicator containing Surgbond should not be dragged on top of the wound. . You need to bring the edges of the wound together

& then apply a few droplets of Surgbond from the applicator at intervals to facilitate holding. 

Please note- Surgbond should not be put directly into the wound. 

If the doctor has not put the droplets properly, then you cannot reapply Surgbond. The doctor needs to reopen the wound again before reapplying Surgbond.

This question does not arise because Surgbond is automatically dissolved into the skin without any scarring effect.

Contact with water should be avoided for at least 4 days after closure with Surgbond. This point is applicable if Surgbond is applied on our epidermis. 

However, for dental procedures, a person can drink water after 1 hour of applying Surgbond. However, he/she should not drink anything hot (tea, coffee, or water) for the next 4 days.

If the stabbing/wound is very deep, then internal absorbable sutures should be applied. However, you can put Surgbond before the final closure of the wound on the epidermis to prevent a long-lasting scarring effect on the skin.

Time taken will entirely depend on the body organ to be operated on. 93% of the cases drying happens immediately. If the surgery is on the skin- then it should happen immediately.

However, if the surgery is on the liver, where blood pressure is high, then it will take more time to dry. Esophagus where the blood pressure is less, drying will be much faster (immediate to 90 secs).

For example- a normal appendicitis operation takes 30 mins to 1 hour. However, sometimes the appendix gets attached to the pelvis or large intestine & hence in such a scenario the operation can go up to a few hours. The same is the case with Surgbond. 

• • For closing laparoscopic port sites in dogs.

• • Biocompatibility of n-butyl-2-cyanoacrylate in cervical structures of rats

Yes it can be applied on a wound, which is 2-3 days old provided no pus is coming out from the area & there is no infection in the area of the wound. 

We have to clean the area of the wound with iodine solution (or Dettol) and then apply Surgbond. 

However, in case of a deep wound, which has resulted in a muscle break due to a road accident, then it will be the doctor’s discretion whether to apply Surgbond or not. Generally, the doctor will do suturing inside & apply Surgbond on the epidermis. 

Surgbond is found to remain stable at Zone 4B stability conditions. Hence, even if someone comes in contact with an environment, which is extremely hot & humid, Surgbond will not have any effects. 

When applied over a surgical wound, Surgbond hardens almost immediately (30 seconds to a few minutes) & formsa strong bond. However, if you still want to reduce skin tension, then you can put surgical stickers on top after applying Surgbond. 

There are a number of articles available, which proves that n-Butyl 2 Cyanoacrylate is both anti-bacterial & anti-fungal in nature. However, there are not much data available to find out what induces these activities in n-Butyl 2 Cyanoacrylate. It might be due to the chemical structure of n-Butyl 2 Cyanoacrylate.

Embolism happens when air is captured or held inside during surgery. For surgeries like gastric varices and varicose veins, Surgbond is applied on the surface. Hence, there are no chances of embolism.

For esophageal surgery, chances of embolism are minuscule, as the doctor will first restrict the wound before applying Surgbond.

Varicose veins are generally treated by 5 therapies-sclerotherapy, surface laser, phlebectomy, endovenous ablation & vein stripping. Sclerotherapy and surface laser do not cause any major wounds. 

For Phlebectomy, a tiny cut is made is in the skin over the vein, and then the vein is pulled out & removed. 

For endovenous ablation (wherein deeper varicose veins are treated)- 

(I) a catheter containing n-Butyl 2 Cyanoacrylate is inserted through a small cut into the vein

(ii) The catheter is used to induce heat into the vein using n-Butyl 2 Cyanoacrylate. 

(iii) The heat closes off the vein & causes it to fade away. 

For Vein stripping also the vein is pulled out after making a number of cuts in the skin on the vein.

For Phlebectomy and vein stripping- Surgbond can be applied to close the wound area for preventing any scarring.

Dehiscence will depend entirely on the area to be applied. If Surgbond is applied on the calf muscle, buttock muscle, or any other part of the body where there is a lot of movement, then there is a chance of dehiscence, as the muscle inside our body takes a couple of days to get healed. Hence, for deeper wounds in this part of the body, it is always better to use sutures

inside & then apply Surgbond on the epidermis.

You can also check the following videos:

https://www.youtube.com/watch?v=tQhYmFYMWHI (gastric varices)

https://www.youtube.com/watch?v=jMCshtXnWzI (this is in Hindi- please listen to this for the first 2 mins)

https://www.youtube.com/watch?v=B6DSfmM55Cw (0.5 ml glue for gastric varices)

Fibrin Glue contains packaged human fibrinogen and human thrombin factor 8 whereas, Surgbond contains n-butyl 2 cyanoacrylate (or n-butyl cyanoacrylate), a cyanoacrylate ester, is a butyl ester of 2-cyano-2-propenoic acid.

The indications of both the products are the same. 

However, Fibrin Glue comes at a much higher price than n-butyl cyanoacrylate. 

It depends on the length of the  cut/wound. We have 3 different strengths- 0.25ml, 0.50 ml and 1.00 ml.

An ampoule of 0.25 ml is used to close a wound of 5 cm, 0.50 ml is used to close a wound of 10 cm & 1.00 ml is used to close a wound of 20 cm. 

In the International market- Surgbond 0.25 ml & Surgbond 0.50 ml are doing well.

I hope that the doctor has used internal sutures, and on the epidermal layer, he has used Surgbond. We have already informed you that in the area where the movement is high like in this part of the body, the doctor has to put medical stickers on top after applying Surgbond. The number of stickers to be used will depend on the area of the body. If it is a leg or hand, then 1-2 stickers are enough, but here for Myomectomy, the doctor may need to apply 4-5 stickers.

If there is too much heat in the environment at the time of applying Surgbond, then the polymerization won’t happen.

It will solidify within a few seconds.

Surgbond can definitely be used in cleft lip and cleft palate surgeries. Our client in Zimbabwe has promoted Surgbond for cleft palate surgery.

The product has already been used on 80 children, and only 7 children came back after 1 week to the doctor just for a normal check-up.

There are a lot of journals, references, and YouTube videos available to prove that the molecule present in Surgbond can be used for cleft palate surgery.

The procedure is relatively painless and quick. Added to this are the benefits of protection from wound infection since the material is bacteriostatic.

There will be a bit of body fluid. For applying Surgbond, the area may not be completely dry. 

Cut the area- blood starts coming out - stop the oozing blood by using running water/distilled water & cotton - bring the edges of the skin together & put Surgbond - the edges of the wound will close almost instantaneously.

In Mucogingival or apicoectomy, there are certain critical complications, which require the use of sutures in the muscle. Hence, in such cases, Surgbond is used only during the closure of the wound on the topmost layer of the wound area.

Cyanoacrylate adhesives become hard in the presence of fluids such as blood or saliva, with good biodegradability and hemostatic and bacteriostatic properties. The simple and fast application of cyanoacrylate adhesives, along with their good hemostatic properties, allows the satisfactory closure of oral mucosal wounds.

Surgbond has not been evaluated in patients with a history of hypertrophic scarring or keloid information.

Surgbond can open up only if it is applied on areas of increased skin tension such as the elbows, knees, or knuckles.

For wounds at risk for tension, provide relief of potential stress along the wound line by approximating wound edges with subcuticular sutures before applying Surgbond to the skin surface, or after applying Surgbond put a medical-grade sticker, so as to avoid tension in the area.

Coughing and carrying lightweight will not result in the reopening of the wound.

Nothing. After you have put Surgbond, the closing of the edges of the wound will happen almost instantaneously. 

However, as mentioned in Point 4, if Surgbond is applied on any part of of body where tension is high such as elbows, knees, or knuckles, ask the patient to be careful, and for safety, you can put a medical-grade sticker on top of the wound after you have applied Surgbond (not immediately, but after a couple of minutes later).

The use of n-butyl 2 cyanoacrylate topical skin adhesives in skin closure following repair of Achilles tendon rupture showed higher patient satisfaction, with equivalent effectiveness and safety compared to conventional nylon skin sutures.

This adhesive polymerizes when formed into a thin film, developing around 50% of its ultimate strength within 1 hour. And, therefore, potentially useful in tendon repair in terms of its strength.

Cyanoacrylate tissue adhesives are considered the standard of care for impending or manifest corneal perforations. They have manifold benefits, including ease of application and antibacterial activity, as well as their ability to offer tectonic support and arrest the progression of keratolysis.

Surgbond glue was drawn up into a sterile 1.0mL syringe, the corneal surface was dried using sterile cotton spears and a small amount of glue was carefully dropped over the perforation site with a 27-gauge needle. The glue was left to set over for at least 30 seconds.

Refer to these articles-

1. https://www.longdom.org/open-access/the-efficacy-of-nbutyl2-cyanoacrylate-histoacryl-for-sealing-corneal-perforation-a-clinical-case-series-and-review-of-th-50070.html#:~:text=Necrotic%20tissue%20on%20the%20ocular,with%20a%2027%2Dgauge%20needle.
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851054/

Surgbond interacts with tissues in a stable way over time (about 7 to 10 days). In addition, they polymerize in contact with skin and especially with mucosa, since this process is accelerated by moisture, forming very strong bonds.